The liver function test was performed by means of two radioisotope tracer techniques in 20 normal subjects and in 63 patients with hepatobiliary diseases. The blood disappearance rates of 1311-rose bengal and of ´"Au colloid were determined by external counting method. The hepatocellular function and the hepatic blood flow were estimated from the observed data andthe results were compared with those of the conventional liver function tests.
The results obtained were as follows:
1. The mean blood disappearance half time of 1311-rose bengal was 6.6±0.63 minutes in normal control, 17.7±6.93 in cirrhosis of the li% er, 16.6±4.80 in acute hepatitis, and 14.7± 3. 46 in obstructive jaundice. It was markedly prolonged in the hepatobiliary diseases as compared with the normal control, but there was no significant difference among the hepatobiliary diseases.
2. The mean blood disappearance half time of ´"Au colloid was 4.0±0.66 minutes in normal´ control, 9. 8±3. 42 in cirrhosis of the liver, 4. 4±0. 82 in acute hepatitis, and 5. 0±1. 42 in obstructive jaundice. The difference between cirrhosis of the liver and normal control wasstatistically significant. However, there was no definite difference among acute hepatitis, obstructive jaundice, and normal control.
The mean blood disappearance rate constant (K value) was 0. 177±0.028/minute in normal´ control. In cirrhosis of the liver, it was markedly decreased which was suggestive of the reduced hepatic blood flow.
3. The ratio of 1311-rose bengal blood disappearance half time to ´"Au colloid disappearance half time was 1.68±0.20 in normal control, 1.82±0.31 in cirrhosis of the liver, 3.80±0.82 in acute hepatitis, and 3. 01±0. 54 in obstructive jaundice. The ratios in acute hepatitis and obst. ructive jaundice were remarkably higher than those in normal control and cirrhosis of the liver.
4. There was a significant correlation between the blood disappearance half time of 1311-rose
bengal and that of 1°8Au colloid in cirrhosis of the liver.
5. In cirrhosis of the liver, the blood disappearance half times of ´-"I-rose bengal and of "´Au colloid were inversely correlated to the serum albumin level. In acute hepatitis, there was a good positive correlation between the blood disappearance half time of 13 11-rose bengal and the serum transaminase activities. In obstructive jaundice, the blood disappearance half time of
1311-rose bengal was correlated to the serum bilirubin level.
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